PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G51140.1
Common NameAKS1, BHLH122, EN70, F23H24.3, FBH3
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 379aa    MW: 41716.4 Da    PI: 6.9134
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G51140.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH37.73.7e-12316361655
                  HHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   6 nerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +++Er RR +i +++ +L++l+P+     ++  + a++L +Av+YIk+Lq
  AT1G51140.1 316 SIAERVRRTKISERMRKLQDLVPNM----DTQTNTADMLDLAVQYIKDLQ 361
                  689*********************7....79******************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.072310360IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.49E-16313376IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.09E-12314365No hitNo description
Gene3DG3DSA:4.10.280.109.4E-16315372IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000104.0E-9316361IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.4E-13316366IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010119Biological Processregulation of stomatal movement
GO:0042335Biological Processcuticle development
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoter
GO:0048573Biological Processphotoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0001046Molecular Functioncore promoter sequence-specific DNA binding
GO:0001228Molecular Functiontranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 379 aa     Download sequence    Send to blast
MESEFQQHHF LLHDHQHQRP RNSGLIRYQS APSSYFSSFG ESIEEFLDRP TSPETERILS  60
GFLQTTDTSD NVDSFLHHTF NSDGTEKKPP EVKTEDEDAE IPVTATATAM EVVVSGDGEI  120
SVNPEVSIGY VASVSRNKRP REKDDRTPVN NLARHNSSPA GLFSSIDVET AYAAVMKSMG  180
GFGGSNVMST SNTEASSLTP RSKLLPPTSR AMSPISEVDV KPGFSSRLPP RTLSGGFNRS  240
FGNEGSASSK LTALARTQSG GLDQYKTKDE DSASRRPPLA HHMSLPKSLS DIEQLLSDSI  300
PCKIRAKRGC ATHPRSIAER VRRTKISERM RKLQDLVPNM DTQTNTADML DLAVQYIKDL  360
QEQVKALEES RARCRCSSA
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.191550.0leaf| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306949050.0
Genevisible245748_at0.0
Expression AtlasAT1G51140-
AtGenExpressAT1G51140-
ATTED-IIAT1G51140-
Function -- GeneRIF ? help Back to Top
  1. These results suggest that bHLH122 functions as a positive regulator of drought, sodium chloride and osmotic signaling.
    [PMID: 24261563]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00195DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G51140.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G51140
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0349410.0AY034941.1 Arabidopsis thaliana unknown protein (At1g51140) mRNA, complete cds.
GenBankAY0631200.0AY063120.1 Arabidopsis thaliana unknown protein (At1g51140) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_564583.10.0transcription factor bHLH122
SwissprotQ9C6900.0BH122_ARATH; Transcription factor bHLH122
TrEMBLD7KHN30.0D7KHN3_ARALL; Basic helix-loop-helix family protein
STRINGAT1G51140.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM105472632
Representative plantOGRP5111580
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  6. Rizhsky L, et al.
    When defense pathways collide. The response of Arabidopsis to a combination of drought and heat stress.
    Plant Physiol., 2004. 134(4): p. 1683-96
    [PMID:15047901]
  7. Xin Z,Mandaokar A,Chen J,Last RL,Browse J
    Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.
    Plant J., 2007. 49(5): p. 786-99
    [PMID:17316173]
  8. Peng M,Bi YM,Zhu T,Rothstein SJ
    Genome-wide analysis of Arabidopsis responsive transcriptome to nitrogen limitation and its regulation by the ubiquitin ligase gene NLA.
    Plant Mol. Biol., 2007. 65(6): p. 775-97
    [PMID:17885809]
  9. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  10. Reiland S, et al.
    Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.
    Plant Physiol., 2009. 150(2): p. 889-903
    [PMID:19376835]
  11. Ito S, et al.
    FLOWERING BHLH transcriptional activators control expression of the photoperiodic flowering regulator CONSTANS in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2012. 109(9): p. 3582-7
    [PMID:22334645]
  12. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  13. Wang P, et al.
    Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(27): p. 11205-10
    [PMID:23776212]
  14. Takahashi Y, et al.
    bHLH transcription factors that facilitate K⁺ uptake during stomatal opening are repressed by abscisic acid through phosphorylation.
    Sci Signal, 2013. 6(280): p. ra48
    [PMID:23779086]
  15. Liu W, et al.
    bHLH122 is important for drought and osmotic stress resistance in Arabidopsis and in the repression of ABA catabolism.
    New Phytol., 2014. 201(4): p. 1192-204
    [PMID:24261563]
  16. Li S, et al.
    CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis.
    PLoS Genet., 2016. 12(1): p. e1005744
    [PMID:26745719]